Human pathogens and vaccine development: New perspective

Development of a New Live Attenuated Mumps Virus Vaccine in Human Deploid Cells

The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine Development

Infectious diseases are a leading cause of morbidity and mortality worldwide, and vaccines are one of the most successful and cost-effective tools for disease prevention. One of the key considerations for rational vaccine development is the selection of appropriate antigens. Antigens must induce a protective immune response, and this response should be directed to stably expressed antigens so t...

Human Papillomavirus Vaccine: Its Application and Perspective

Two prophylactic vaccines against HPV16 and 18 infections are commercially available. Published clinical trials with these HPV vaccines report their use in protection against cervical CIN2+ if girls are vaccinated before their sexual debut. Even though HPV 16 and 18 cause approximately 70% of cervical cancer and an almost 100% of effectiveness would be expected against these cancers, other type...

Development of Vaccine Adjuvants: a Historical Perspective

Since the earliest attempts to raise signifi cant immune responses against nonliving agents, investigators have tried to identify useful additives that can be combined with antigens to enhance immune responses. Such immuneenhancing additives are known as adjuvants. Virtually all adjuvant systems developed to date have focused on one of two mechanisms: specifi c immune activation or the delivery...

Development of male contraceptive vaccine--a perspective.

This paper reviews the recent advances that have occurred in the area of development of a male contraceptive vaccine. The vaccine candidates considered for review are hormone/hormone receptor-based proteins including luteinizing hormone-releasing hormone (LHRH)/LH, follicle stimulating hormone (FSH), as well as LH and FSH receptor proteins. The review also highlights the advances in our basic u...